1. What is Transferrin Saturation (TSAT)?

Transferrin saturation (TSAT) measures the percentage of iron-binding sites on transferrin that are occupied by iron. It's a key indicator of iron status in the body and helps diagnose iron deficiency or iron overload conditions.

2. How Does the Calculator Work?

The calculator uses the TSAT equation:

Where:

• \( Serum\ Iron \) — Iron concentration in blood (μg/dL)
• \( TIBC \) — Total Iron-Binding Capacity (μg/dL)

Explanation: The equation calculates what percentage of available iron-binding sites on transferrin are actually bound to iron.

3. Importance of TSAT Calculation

Details: TSAT is crucial for diagnosing and monitoring iron metabolism disorders. Low TSAT suggests iron deficiency, while high TSAT may indicate iron overload or hemochromatosis.

4. Using the Calculator

Tips: Enter serum iron and TIBC values in μg/dL. Both values must be positive numbers. For accurate results, tests should be performed fasting in the morning.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TSAT value?
A: Normal range is typically 20-50%. Values below 20% suggest iron deficiency, while above 50% may indicate iron overload.

Q2: How does TSAT differ from ferritin?
A: TSAT reflects current iron availability, while ferritin indicates iron stores. Both are needed for complete iron status assessment.

Q3: When should TSAT be measured?
A: When evaluating anemia, suspected iron disorders, or monitoring iron therapy. Morning fasting samples are preferred.

Q4: What affects TSAT results?
A: Recent iron intake, inflammation, liver disease, and certain medications can influence results.

Q5: Is TSAT used in chronic kidney disease?
A: Yes, TSAT is part of iron status evaluation in CKD patients, especially those on erythropoiesis-stimulating agents.