1. What is Total Iron Saturation (TSAT)?

Total Iron Saturation (TSAT) measures the percentage of iron-binding sites on transferrin that are occupied by iron. It's a key indicator of iron status in the body and helps diagnose iron deficiency or overload.

2. How Does the Calculator Work?

The calculator uses the TSAT equation:

Where:

• \( Total\_iron \) — Serum iron concentration (μg/dL)
• \( TIBC \) — Total iron binding capacity (μg/dL)

Explanation: The equation calculates what percentage of available iron-binding sites on transferrin are actually occupied by iron.

3. Importance of TSAT Calculation

Details: TSAT is crucial for assessing iron status, diagnosing iron deficiency anemia, and monitoring iron overload conditions like hemochromatosis.

4. Using the Calculator

Tips: Enter total iron and TIBC values in μg/dL. Both values must be positive numbers. For accurate results, samples should be collected in the morning after fasting.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TSAT value?
A: Normal range is typically 20-50%. Below 20% suggests iron deficiency, while above 50% may indicate iron overload.

Q2: How does TSAT differ from serum ferritin?
A: TSAT reflects current iron availability, while ferritin reflects iron stores. Both are needed for complete iron status assessment.

Q3: When should TSAT be measured?
A: When evaluating anemia, monitoring iron therapy, or assessing possible iron overload disorders.

Q4: What factors can affect TSAT results?
A: Recent iron intake, inflammation, liver disease, and certain medications can influence results.

Q5: Is fasting required for TSAT testing?
A: While not always required, fasting improves accuracy as dietary iron can temporarily increase serum iron levels.