1. What is Total Lymphocyte Count?

Total Lymphocyte Count (TLC) is a measure of the absolute number of lymphocytes in the blood, calculated from the white blood cell count and lymphocyte percentage. It's used to assess immune function and nutritional status.

2. How Does the Calculator Work?

The calculator uses the Mayo Clinic formula:

Where:

• \( WBC \) — White blood cell count (cells/μL)
• \( Lymph\% \) — Lymphocyte percentage (%)

Explanation: The equation converts the relative lymphocyte percentage to an absolute count by multiplying by the total WBC count.

3. Importance of TLC Calculation

Details: TLC is important for evaluating immune status, particularly in conditions like HIV/AIDS, malnutrition, and post-chemotherapy monitoring.

4. Using the Calculator

Tips: Enter WBC count in cells/μL and lymphocyte percentage (0-100%). Both values must be positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TLC range?
A: Normal range is typically 1,000-4,800 cells/μL in adults, though this varies by age and laboratory.

Q2: What does a low TLC indicate?
A: Lymphopenia (low TLC) may indicate immunodeficiency, viral infections, autoimmune disorders, or malnutrition.

Q3: What does a high TLC indicate?
A: Lymphocytosis (high TLC) may suggest viral infections, chronic inflammatory conditions, or certain leukemias.

Q4: How often should TLC be monitored?
A: Frequency depends on the clinical context - from daily in hospitalized patients to annually in stable conditions.

Q5: Are there limitations to this calculation?
A: While useful, TLC doesn't differentiate lymphocyte subsets (T-cells, B-cells, NK cells) which may be important in specific conditions.