1. What is Transferrin Saturation (TSAT)?

Transferrin saturation (TSAT) measures the percentage of iron-binding sites on transferrin that are occupied by iron. It's an important indicator of iron status in the body and is commonly used to diagnose iron deficiency or iron overload.

2. How Does the Calculator Work?

The calculator uses the TSAT equation:

Where:

• \( Iron \) — Serum iron concentration in μg/dL
• \( TIBC \) — Total iron-binding capacity in μg/dL

Explanation: The equation calculates what percentage of the available iron-binding sites on transferrin are actually bound to iron.

3. Importance of TSAT Calculation

Details: TSAT helps differentiate between different types of anemia and is particularly useful in diagnosing iron deficiency anemia and hereditary hemochromatosis.

4. Using the Calculator

Tips: Enter serum iron and TIBC values in μg/dL. Both values must be greater than 0 for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal TSAT values?
A: Normal range is typically 20-50%. Below 20% suggests iron deficiency, while above 50% may indicate iron overload.

Q2: How does TSAT differ from serum ferritin?
A: TSAT reflects current iron availability, while ferritin reflects iron stores. Both are needed for complete iron status assessment.

Q3: When should TSAT be measured?
A: Morning fasting sample is preferred as iron levels have diurnal variation. Avoid testing after iron supplementation.

Q4: What conditions affect TSAT?
A: Inflammation can lower TSAT independent of iron status. Chronic illness may also affect interpretation.

Q5: How often should TSAT be monitored?
A: Frequency depends on clinical context - typically every 3-6 months during iron therapy or phlebotomy treatment.