1. What is Transferrin Saturation?

Transferrin saturation (TSAT) measures the percentage of iron-binding sites on transferrin that are occupied by iron. It's an important indicator of iron status in the body and helps diagnose iron deficiency or iron overload conditions.

2. How Does the Calculator Work?

The calculator uses the TSAT formula:

Where:

• \( Serum\ Iron \) — Serum iron concentration in μg/dL
• \( TIBC \) — Total iron-binding capacity in μg/dL

Explanation: The formula calculates what percentage of available iron-binding sites on transferrin are actually bound to iron.

3. Importance of TSAT Calculation

Details: TSAT is crucial for evaluating iron metabolism disorders. Low TSAT suggests iron deficiency, while high TSAT may indicate iron overload or hemochromatosis.

4. Using the Calculator

Tips: Enter serum iron and TIBC values in μg/dL. Both values must be positive numbers for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TSAT range?
A: Normal range is typically 20-50%. Values below 20% suggest iron deficiency, while above 50% may indicate iron overload.

Q2: How does TSAT differ from serum ferritin?
A: TSAT reflects current iron availability, while ferritin reflects iron stores. Both are needed for complete iron status assessment.

Q3: When should TSAT be measured?
A: TSAT is useful when evaluating anemia, suspected iron disorders, or monitoring iron therapy in chronic kidney disease patients.

Q4: Are there limitations to TSAT?
A: TSAT can fluctuate with recent iron intake or inflammation. It should be interpreted with other iron studies and clinical context.

Q5: How is TSAT used in CKD patients?
A: In chronic kidney disease, TSAT helps guide iron supplementation and erythropoiesis-stimulating agent therapy.