1. What is Transferrin Saturation (TSAT)?

Transferrin saturation (TSAT) measures the percentage of iron-binding sites on transferrin that are occupied by iron. It's an important indicator of iron status in the body and helps diagnose iron deficiency or iron overload.

2. How Does the Calculator Work?

The calculator uses the TSAT formula:

Where:

• \( Serum\ Iron \) — Serum iron concentration (μg/dL)
• \( TIBC \) — Total iron-binding capacity (μg/dL)

Explanation: The equation calculates what percentage of available iron-binding sites on transferrin are actually bound to iron.

3. Importance of TSAT Calculation

Details: TSAT is crucial for evaluating iron metabolism disorders, diagnosing iron deficiency anemia, and monitoring iron therapy in chronic kidney disease patients.

4. Using the Calculator

Tips: Enter serum iron and TIBC values in μg/dL. Both values must be valid (greater than 0). Fasting samples are preferred for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TSAT value?
A: Normal range is typically 20-50%. Values below 20% suggest iron deficiency, while values above 50% may indicate iron overload.

Q2: How does TSAT differ from serum ferritin?
A: TSAT reflects current iron availability, while ferritin reflects iron stores. Both are needed for complete iron status assessment.

Q3: When should TSAT be measured?
A: When evaluating anemia, monitoring iron therapy, or assessing possible iron overload conditions like hemochromatosis.

Q4: Are there limitations to TSAT?
A: TSAT can fluctuate throughout the day and be affected by inflammation or recent iron intake. It's best measured in the morning after fasting.

Q5: What are typical TIBC values?
A: Normal TIBC ranges from 240-450 μg/dL in adults, but varies by laboratory. Higher in iron deficiency, lower in chronic disease.